Yes, it matters. From the 750x manual:
"Important: The minimum total impedance when operating the 750x is 2.6 ohms. This means you can safely use: a) A single 8 ohm cabinet b) A single 4 ohm cabinet c) Two 8 ohm cabinets (total: 4 ohms) d) One 8 ohm cabinet and one 4 ohm cabinet (total: 2.6 ohms) ** e) Three 8 ohm cabinets (total: 2.6 ohms) ** **Running the amplifier constantly at 2.6 ohms, while technically acceptable, will cause the amp to run hotter than usual, and will cause heat-related wear on components sooner than normal."
You can measure the cab's resistance - usually around 3/4 of its impedance value - with a multimeter. An 8 ohm cab will read ~6 ohms and a 4 ohm cab ~3 ohms.