With a few Jazz pickup changes, yes, the difference was notable and what I was looking for...
A 2000 MIM Jazz 5 that I made fretless - went from stock single-coils to Nord humcanceling models. Big difference. Made the bridge pup usable for that you-know-who sound.
A 2014 AM STD Jazz 5 and an American Elite - changed our pups in both basses to Nord vintage single-coil 70s wind and Nord preamps. Definitely an appreciable difference. Not big, but appreciable.
Mike Lull P5. Changed pup from the custom SD pups to the Nord (see a pattern here?) NP5 Vintage pups. This has been the most noticeable pup change I’ve ever experienced. The SD was nice and polite, knew its place in the mix. I wanted grindy hi-mid Precision growl. And boy, I have it now. Not only is the tone what I’m looking for, but the B string sounds way better and like a Pbass B string should. Also, the high notes still sound like the P bass, too. For my tastes, in Precision bass tones, it’s a serious improvement.
So as always and like it or not....
It depends.....
Sorry.