Tips for preserving tone?

So I took my little pedalboard I've been working on for a couple of weeks (cabin fever project) out for its virgin gig last night. Lots of fun! But at one point I bypassed it and plugged straight into the amp, and was - not shocked, but a little surprised how much tone loss I was suffering. I believe two of my pedals - Joyo and Moorer - are true bypass, and the two Boss and one Digitech are not. Is that the trick, go all true bypass? Anything else I can do to preserve my tone? Or is that just the nature of using multiple effects? (All are powered by a One Spot).
 
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If you really like the sound of your current pedals, but they cause tone suck, purchase a switch/effects loop pedal, so it can be removed from the chain when not in use.

Or you can replace the offending pedals with true bypass.

Either way should solve the issue.

I’d also consider upgrading your power supply, but I don’t know if that would cause issue in tone.
 
I thought having a sorta buffer at the beginning and end of your signal chain was supposed to help with stuff like this? Correct me if I'm wrong but I've heard that running through a bunch of true bypass pedals can kill your tone as much as pedals with poor bypass. If I'm also understanding things correctly having an "always on" pedal at the end like compression or a preamp can act as a buffer....
 
I thought having a sorta buffer at the beginning and end of your signal chain was supposed to help with stuff like this? Correct me if I'm wrong but I've heard that running through a bunch of true bypass pedals can kill your tone as much as pedals with poor bypass. If I'm also understanding things correctly having an "always on" pedal at the end like compression or a preamp can act as a buffer....

All good points. A little help for an old pedal noob here?