It's all about the individual I think. There's nothing wrong with any tuning on your bass, if that's what suits your playing.
I'm a big fan of E-A-D-G-C for instance. It's not the craziest tuning you've ever heard of, but it's also not the most common.
Is there a re-adjustment period when I switch to low-B tuning? there was in the beginning, but I've been doing it for almost 20 years now, so it's very natural.
There are guitarists who tune their guitars in open 4ths all the way across. So C and F on the top, instead of B and E... It all depends what you want out of it.