I’m using a Mesa Buster head as a tube power amp for an Avalon U5 via ‘effects return’.
Sounds absolutely great, and the MV works. Unfortunately the return is post graphic Eq, however the head isn’t really that heavy - and is really, really loud and maintains an incredible clarity. I haven’t had to exceed 50% MV to keep up with a really loud band.
I’ve owned a Mesa 400+, and a Bassman 300 Pro and they were both brutally heavy compared to the Buster.