Sweetest sounding cab I've ever heard is my Bergantino NV610. I used it regularly with a stupid loud band I used to play with that had a bunch of gigs with easy load-ins, but that band fell apart a few years ago. Since then I've been juggling a bunch of bands and sub gigs, but only ever use the 6x10 for the occasional outdoor gig if I know it has an easy load-in.
Aside from size and weight, the other problem with a 6x10 is the intimidation factor: even if your bandmates trust you to use it appropriately, it might cause concern with management at smaller venues, or anyplace concerned about volume.
My alternate rig is a pair of high-efficiency 1x12 cabs that punch well above their size and weight: the only time I've ever wanted more was outdoors at high volume (should have brought the 6x10!) The point is, I recommend a pair of smaller cabs, e.g. 1x12, 2x10. First, there's the modularity factor: I've done plenty of smaller/quieter gigs with a single 1x12, and it's a nice easy schlep. Another big advantage is that it's narrower, taking up less stage space, which can be a huge advantage when crammed into a small area. Even when I was running a pair of 2x10 cabs, I would stack them vertically: takes up less room, gets the drivers closer to ear level where I can hear them better.